Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...

Anorexia nervosa (AN) is an eating disorder, with the significant loss of the adipose tissue. Lack of subcutaneous adipose tissue observed in lipodystrophies is accompanied by insulin resistance. The crucial step in the development of insulin resistance is an impaired increase in carbohydrate oxidation and decrease in lipid oxidation in response to insulin. The aim of the present study was to estimate carbohydrate and lipid oxidation in relation to serum adiponectin concentrat...

Markers of endothelial dysfunction, including soluble E-selectin (sE-selectin) are related to insulin resistance and are predictors of type 2 diabetes. Insulin resistance is associated with metabolic inflexibility, i.e. an impaired stimulation of carbohydrate oxidation and inhibition of lipid oxidation in insulin-stimulated conditions. The aim of the present study was to estimate the relationships of serum sE-selectin concentration with carbohydrate and lipid oxidation in lean...

Background: Obesity is associated with an increased risk of impaired glucose tolerance and type 2 diabetes. Insulin resistance is the link between obesity and disturbances of glucose metabolism. It is suggested that some substances secreted by adipose tissue might play a role in the pathogenesis of insulin resistance. One of these substances is interleukin-6 (IL-6), cytokine, which regulates synthesis of the acute-phase proteins in the liver. The aim of the present study was t...

Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and t...

Introduction: Type B insulin resistance syndrome is an autoimmune disorder characterized by the production of autoantibodies against the insulin receptor. It leads to glucose metabolism disorders, extreme insulin resistance, hyperandrogenism and is associated with other features of autoimmunity.Case report: A 27-year-old man, with a 2-years history of psoriasis, was admitted to our Department because of loss of weight (20 kg in 1 year) and fatigue. He al...

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...

Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL-12 is a proinflammatory cytokine with proatherogenic properties. IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL-12. The aim of the present study was to estimate serum IL-12 and p40 subunit in ...

Polycystic ovary syndrome (PCOS) is heterogeneous disorder leading to infertility. The introduction of Rotterdam criteria creates different PCOS phenotypes, i.e. hyperandrogenic anovulatory with (A) and without (B) polycystic ovaries (PCO) morphology in ultrasonography (usg), hyperandrogenic ovulatory with PCO morphology in usg (C), non-hyperandrogenic anovulatory with PCO morphology in usg (D). In PCOS insulin resistance might be involved in the development of endocrine and m...

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...